A live single-cell reporter assay links intratumor heterogeneity to metastatic proclivity in Ewing sarcoma
نویسندگان
چکیده
A miRNA-based in vivo reporter deciphers cell heterogeneity Ewing sarcoma.
منابع مشابه
ERBB4 confers metastatic capacity in Ewing sarcoma
Metastatic spread is the single-most powerful predictor of poor outcome in Ewing sarcoma (ES). Therefore targeting pathways that drive metastasis has tremendous potential to reduce the burden of disease in ES. We previously showed that activation of the ERBB4 tyrosine kinase suppresses anoikis, or detachment-induced cell death, and induces chemoresistance in ES cell lines in vitro. We now show ...
متن کاملCurrent Therapeutic Approaches in Metastatic and Recurrent Ewing Sarcoma
Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches...
متن کاملClinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma
We report a response to pazopanib in a 69-year-old man with heavily pre-treated metastatic extraosseous Ewing sarcoma in addition to molecular profiling of his tumor. To our knowledge, this case is the earliest to demonstrate activity of an oral multi-targeted kinase inhibitor in Ewing sarcoma. This case provides rationale for adding a Ewing sarcoma arm to SARC024, a phase II study of regorafen...
متن کاملDKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma.
Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we identified the pro-metastatic gene DKK2 as a highly overexpressed gene in Ewing sarcoma compared with corresponding normal tissues. Using RNA interference, we showed that DKK2 was critical for malignant cell outgrowth in vitro and in an ...
متن کاملIntratumor heterogeneity in HCC
(HCC) is the second most common cause of cancer-related death worldwide [1], generally arising on the background of chronic liver diseases such as chronic viral hepatitis, alcohol-induced liver injury, or fatty liver disease. So far, classification proposals for HCC based on molecular markers are not yet routinely applied in surgical pathology or clinical management of HCC patients. This stands...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science Advances
سال: 2021
ISSN: ['2375-2548']
DOI: https://doi.org/10.1126/sciadv.abf9394